Iron(I) in Negishi Cross-Coupling Reactions

被引：150

作者：

Adams, Christopher J. ^{[1
]}

Bedford, Robin B. ^{[1
]}

Carter, Emma ^{[2
]}

Gower, Nicholas J. ^{[1
]}

Haddow, Mairi F. ^{[1
]}

Harvey, Jeremy N. ^{[1
]}

Huwe, Michael ^{[1
]}

Angeles Cartes, M. ^{[3
]}

Mansell, Stephen M. ^{[1
]}

Mendoza, Carla ^{[1
]}

Murphy, Damien M. ^{[2
]}

Neeve, Emily C. ^{[1
]}

Nunn, Joshua ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Cardiff Univ, Sch Chem, Cardiff CF10 3TB, S Glam, Wales

[3] Univ Seville, CSIC, Inst Invest Quim, Seville 41092, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 25期

基金：

英国工程与自然科学研究理事会;

关键词：

ALKYL-HALIDES; GRIGNARD REAGENTS; COMPLEXES; LIGAND; REACTIVITY; CATALYSIS;

D O I：

10.1021/ja303250t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we demonstrate both the importance of Fe(I) in Negishi cross-coupling reactions with arylzinc reagents and the isolation of catalytically competent Fe(I) intermediates. These complexes, [FeX-(dpbz)(2)] [X = 4-tolyl (7), Cl (8a), Br (8b); dpbz = 1,2-bis(diphenylphosphino)benzene], were characterized by crystallography and tested for activity in representative reactions. The complexes are low-spin with no significant spin density on the ligands. While complex 8b shows performance consistent with an on-cycle intermediate, it seems that 7 is an off-cycle species.

引用

页码：10333 / 10336

页数：4

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