Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target

被引:340
作者
Evans, Christopher G.
Chang, Lyra
Gestwicki, Jason E. [1 ]
机构
[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
关键词
HEAT-SHOCK PROTEINS; N-TERMINAL KINASE; IMMUNOSUPPRESSIVE ACTIVITY RELATIONSHIPS; ANDROGEN RECEPTOR PROTEIN; CO-CHAPERONE HOP; MOLECULAR CHAPERONES; IN-VITRO; ATPASE ACTIVITY; CANCER-CELLS; ANTITUMOR-ACTIVITY;
D O I
10.1021/jm100054f
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:4585 / 4602
页数:18
相关论文
共 243 条
[81]  
HOEGER PH, 1994, J IMMUNOL, V153, P3908
[82]  
Hoffman P S, 1999, Infect Dis Obstet Gynecol, V7, P58, DOI 10.1002/(SICI)1098-0997(1999)7:1/2<58::AID-IDOG12>3.3.CO
[83]  
2-1
[84]   From the cradle to the grave:: molecular chaperones that may choose between folding and degradation [J].
Höhfeld, J ;
Cyr, DM ;
Patterson, C .
EMBO REPORTS, 2001, 2 (10) :885-890
[85]   Heat-shock protein 70 exerts opposing effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophages [J].
Iordanskiy, S ;
Zhao, YQ ;
DiMarzio, P ;
Agostini, I ;
Dubrovsky, L ;
Bukrinsky, M .
BLOOD, 2004, 104 (06) :1867-1872
[86]   Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity [J].
Jana, NR ;
Tanaka, M ;
Wang, GH ;
Nukina, N .
HUMAN MOLECULAR GENETICS, 2000, 9 (13) :2009-2018
[87]   Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes [J].
Jana, NR ;
Dikshit, P ;
Goswami, A ;
Kotliarova, S ;
Murata, S ;
Tanaka, K ;
Nukina, N .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (12) :11635-11640
[88]   Structural basis of J cochaperone binding and regulation of Hsp70 [J].
Jiang, Jianwen ;
Maes, E. Guy ;
Taylor, Alexander B. ;
Wang, Liping ;
Hinck, Andrew P. ;
Lafer, Eileen M. ;
Sousa, Rui .
MOLECULAR CELL, 2007, 28 (03) :422-433
[89]   Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability [J].
Jinwal, Umesh K. ;
Miyata, Yoshinari ;
Koren, John, III ;
Jones, Jeffrey R. ;
Trotter, Justin H. ;
Chang, Lyra ;
O'Leary, John ;
Morgan, David ;
Lee, Daniel C. ;
Shults, Cody L. ;
Rousaki, Aikaterini ;
Weeber, Edwin J. ;
Zuiderweg, Erik R. P. ;
Gestwicki, Jason E. ;
Dickey, Chad A. .
JOURNAL OF NEUROSCIENCE, 2009, 29 (39) :12079-12088
[90]   HspBP1, a homologue of the yeast Fes1 and S1s1 proteins, is an Hsc70 nucleotide exchange factor [J].
Kabani, M ;
McLellan, C ;
Raynes, DA ;
Guerriero, V ;
Brodsky, JL .
FEBS LETTERS, 2002, 531 (02) :339-342