Changes in IGF-1 receptors in the hippocampus of adult rats after long-term adrenalectomy:: receptor autoradiography and in situ hybridization histochemistry

被引：14

作者：

Islam, A

Ayer-LeLievre, C

Heigensköld, C

Bogdanovic, N

Winblad, B

Adem, A

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Geriatr Sect, Dept Clin Neurosci & Family Med, S-14186 Huddinge, Sweden

[2] CNRS, URA, Lab Biochim Med, Limoges, France

来源：

BRAIN RESEARCH | 1998年 / 797卷 / 02期

关键词：

neurodegeneration; apoptosis; corticosteroid; growth factor;

D O I：

10.1016/S0006-8993(98)00389-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alteration of insulin-like growth factor-1 (IGF-1) receptor and its mRNA after long-term adrenalectomy (ADX) was studied in the hippocampus by in vitro receptor autoradiography and in situ hybridization histochemistry, respectively. Significantly, decreased levels of IGF-1 receptor and its mRNA was noted in the dentate and CA1-CA4 regions of the hippocampus of the ADX animals, suggesting that the level and expression of IGF-1 receptors in the hippocampus is influenced by adrenal hormones. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：342 / 346

页数：5

共 20 条

[1]

ADAMO M, 1988, Endocrinology, V123, P2565

[2] INSULIN-LIKE GROWTH FACTOR-I (IGF-1) RECEPTORS IN THE HUMAN-BRAIN - QUANTITATIVE AUTORADIOGRAPHIC LOCALIZATION [J].