Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

被引:72
作者
Goldbach-Mansky, R
Lee, JM
Hoxworth, JM
Smith, D
Duray, P
Schumacher, HR
Yarboro, CH
Klippel, J
Kleiner, D
El-Gabalawy, HS
机构
[1] NIAMSD, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA
[2] NIH, Dept Pathol, Bethesda, MD 20892 USA
[3] Univ Penn, Sch Med, Philadelphia, PA 19104 USA
[4] Vet Affairs, Philadelphia, PA USA
关键词
early synovitis; erosion; metalloproteinase; matrix metalloproteinase-2; rheumatoid arthritis;
D O I
10.1186/ar79
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.
引用
收藏
页码:145 / 153
页数:9
相关论文
共 55 条
[41]  
Takagi M, 1998, LAB INVEST, V78, P735
[42]   Postsurgical wound progression monitored by temporal changes in the expression of matrix metalloproteinase-9 [J].
Tarlton, JF ;
Vickery, CJ ;
Leaper, DJ ;
Bailey, AJ .
BRITISH JOURNAL OF DERMATOLOGY, 1997, 137 (04) :506-516
[43]   CONSTITUTIVE EXPRESSION OF A 92-KD GELATINASE (TYPE-V COLLAGENASE) BY RHEUMATOID SYNOVIAL FIBROBLASTS AND ITS INDUCTION IN NORMAL HUMAN FIBROBLASTS BY INFLAMMATORY CYTOKINES [J].
UNEMORI, EN ;
HIBBS, MS ;
AMENTO, EP .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (05) :1656-1662
[44]   USING INHIBITORS OF METALLOPROTEINASES TO TREAT ARTHRITIS - EASIER SAID THAN DONE [J].
VINCENTI, MP ;
CLARK, IM ;
BRINCKERHOFF, CE .
ARTHRITIS AND RHEUMATISM, 1994, 37 (08) :1115-1126
[45]   MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes [J].
Vu, TH ;
Shipley, JM ;
Bergers, G ;
Berger, JE ;
Helms, JA ;
Hanahan, D ;
Shapiro, SD ;
Senior, RM ;
Werb, Z .
CELL, 1998, 93 (03) :411-422
[46]   ENDOGENOUS ACTIVATION OF LATENT COLLAGENASE BY RHEUMATOID SYNOVIAL CELLS - EVIDENCE FOR A ROLE OF PLASMINOGEN ACTIVATOR [J].
WERB, Z ;
MAINARDI, CL ;
VATER, CA ;
HARRIS, ED .
NEW ENGLAND JOURNAL OF MEDICINE, 1977, 296 (18) :1017-1023
[47]  
WILHELM SM, 1990, J BIOL CHEM, V265, P22570
[48]  
WILHELM SM, 1989, J BIOL CHEM, V264, P17213
[49]   Matrix metalloproteinase inhibitors [J].
WojtowiczPraga, SM ;
Dickson, RB ;
Hawkins, MJ .
INVESTIGATIONAL NEW DRUGS, 1997, 15 (01) :61-75
[50]  
Wolfe F, 1996, J RHEUMATOL, V23, P13