Synchrotron hard x-ray microprobe:: Fluorescence imaging of single cells

被引：86

作者：

Bohic, S

Simionovici, A

Snigirev, A

Ortega, R

Devès, G

Heymann, D

Schroer, CG

机构：

[1] European Synchrotron Radiat Facil, F-38043 Grenoble, France

[2] Univ Bordeaux 1, LCNAB, CNRS, UMR 5084, F-33175 Gradignan, France

[3] Lab Physiopatol Resorpt Osseuse, Nantes, France

[4] Rhein Westfal TH Aachen, Inst Phys 2, D-52056 Aachen, Germany

来源：

APPLIED PHYSICS LETTERS | 2001年 / 78卷 / 22期

关键词：

D O I：

10.1063/1.1366362

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Imaging of trace elements in single cells was achieved by synchrotron-induced x-ray fluorescence (SXRF) in the hard x-ray range. Monochromatic and "pink" excitations at 14 keV were used with compound refractive lenses resulting in a 1x10 mum(2) beam size. The experiment shows that SXRF is well suited for microanalysis of freeze-dried cells, and demonstrated high accuracy in quantitative imaging of trace element in cells treated with pharmacological doses of an iodine-labeled anticancer drug. (C) 2001 American Institute of Physics.

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页码：3544 / 3546

页数：3

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