The 2002 Bernard B. Brodie Award Lecture - Deciphering substrate recognition by drug-metabolizing cytochromes P450

被引：29

作者：

Johnson, EF ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, MEM 255, La Jolla, CA 92037 USA

来源：

DRUG METABOLISM AND DISPOSITION | 2003年 / 31卷 / 12期

关键词：

D O I：

10.1124/dmd.31.12.1532

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：1532 / 1540

页数：9

共 65 条

[31] DETECTION, DELINEATION, MEASUREMENT AND DISPLAY OF CAVITIES IN MACROMOLECULAR STRUCTURES [J].

KLEYWEGT, GJ ;

JONES, TA .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 :178-185

[32] MOLSCRIPT - A PROGRAM TO PRODUCE BOTH DETAILED AND SCHEMATIC PLOTS OF PROTEIN STRUCTURES [J].

KRAULIS, PJ .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1991, 24 :946-950

[33] A rational approach to re-engineer cytochrome P4502B1 regioselectivity based on the crystal structure of cytochrome P4502C5 [J].

Kumar, S ;

Scott, EE ;

Liu, H ;

Halpert, JR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :17178-17184

[34]

LEVIN W, 1990, DRUG METAB DISPOS, V18, P824

[35] The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid [J].

Li, HY ;

Poulos, TL .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (02) :140-146

[36]

LU AY, 1996, DRUG METAB DISPOS, V26, P1168

[37]

MANNERING GJ, 1986, DRUG METAB DISPOS, V14, P1

[38] Sulfaphenazole derivatives as tools for comparing cytochrome P4502C5 and human cytochromes P4502Cs: Identification of a new high affinity substrate common to those enzymes [J].

Marques-Soares, C ;

Dijols, S ;

Macherey, AC ;

Wester, MR ;

Johnson, EF ;

Dansette, PM ;

Mansuy, D .

BIOCHEMISTRY, 2003, 42 (21) :6363-6369

[39] METABOLIC PROCESSING OF 2-ACETYLAMINOFLUORENE BY MICROSOMES AND 6 HIGHLY PURIFIED CYTOCHROME-P-450 FORMS FROM RABBIT LIVER [J].

MCMANUS, ME ;

MINCHIN, RF ;

SANDERSON, N ;

SCHWARTZ, D ;

JOHNSON, EF ;

THORGEIRSSON, SS .

CARCINOGENESIS, 1984, 5 (12) :1717-1723

[40] Raster3D: Photorealistic molecular graphics [J].

Merritt, EA ;

Bacon, DJ .

MACROMOLECULAR CRYSTALLOGRAPHY, PT B, 1997, 277 :505-524

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