Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

被引:585
作者
Limmer, A
Ohl, J
Kurts, C
Ljunggren, HG
Reiss, Y
Groettrup, M
Momburg, F
Arnold, B
Knolle, PA [1 ]
机构
[1] ZMBH, D-69120 Heidelberg, Germany
[2] Med Hsch Hannover, Dept Nephrol, Hannover, Germany
[3] Karolinska Inst, Ctr Microbiol & Tumor Biol, Stockholm, Sweden
[4] Tel Aviv Univ, Dept Biochem, IL-69978 Tel Aviv, Israel
[5] Cantonal Hosp St Gall, Res Dept, St Gallen, Switzerland
[6] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany
关键词
D O I
10.1038/82161
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Myeloid antigen-presenting cells (APC) are known to cross-present exogenous antigen on major histocompatibility class I molecules to CD8(+) T cells and thereby induce protective immunity against infecting microorganisms. Here we report that liver sinusoidal endothelial cells (LSEC) are organ-resident, non-myeloid APC capable of cross-presenting soluble exogenous antigen to CD8(+) T cells. Though LSEC employ similar molecular mechanisms for cross-presentation as dendritic cells, the outcome of cross-presentation by LSEC is CD8(+) T cell tolerance rather than immunity. As uptake of circulating antigens into LSEC occurs efficiently in vivo, it is likely that cross-presentation by LSEC contributes to CD8(+) T cell tolerance observed in situations where soluble antigen is present in the circulation.
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页码:1348 / 1354
页数:7
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