Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

被引：153

作者：

Abel, Ted ^{[3
]}

Nguyen, Peter V. ^{[1
,2
]}

机构：

[1] Univ Alberta, Sch Med, Dept Physiol, Ctr Neurosci, Edmonton, AB T6G 2H7, Canada

[2] Univ Alberta, Sch Med, Dept Psychiat, Ctr Neurosci, Edmonton, AB T6G 2H7, Canada

[3] Univ Penn, Dept Biol, Biol Basis Behav Program, Philadelphia, PA 19104 USA

来源：

ESSENCE OF MEMORY | 2008年 / 169卷

关键词：

memory; learning; cyclic AMP-dependent protein kinase; hippocampus; synaptic plasticity; long-term potentiation;

D O I：

10.1016/S0079-6123(07)00006-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.

引用

页码：97 / 115

页数：19

共 170 条

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