Recent highlights in the pathophysiology of atopic eczema

被引:20
作者
Allam, JP [1 ]
Bieber, T [1 ]
Novak, N [1 ]
机构
[1] Univ Bonn, Dept Dermatol, DE-53105 Bonn, Germany
关键词
atopic eczema; chemokines; dendritic cells; cytokines; genetics;
D O I
10.1159/000083893
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Atopic eczema (AE) belongs to the group of atopic diseases that have become increasingly prevalent over the last decades. The pathophysiology of AE has long remained enigmatic, but much scientific effort has been invested in elucidating the genetic background and the immunological mechanisms underlying AE, leading to a better understanding of this complex disease and to new therapeutic strategies. This review provides an update on the scientific progress that has been achieved in clarifying the pathophysiological mechanisms of AE. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码:191 / 197
页数:7
相关论文
共 50 条
[1]   The Toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype [J].
Ahmad-Nejad, P ;
Mrabet-Dahbi, S ;
Breuer, K ;
Klotz, M ;
Werfel, T ;
Herz, U ;
Heeg, K ;
Neumaier, M ;
Renz, H .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (03) :565-567
[2]   T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells [J].
Akdis, M ;
Trautmann, A ;
Klunker, S ;
Daigle, I ;
Küçüksezer, UC ;
Deglmann, W ;
Disch, R ;
Blaser, K ;
Akdis, CA .
FASEB JOURNAL, 2003, 17 (09) :1026-1035
[3]   Transforming growth factor-β1 regulates the expression of the high-affinity receptor for IgE on CD34+ stem cell-derived CD1a+ dendritic cells in vitro [J].
Allam, JP ;
Klein, E ;
Bieber, T ;
Novak, N .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (04) :676-682
[4]   Atopic dermatitis is associated with a low-producer transforming growth factor β1 cytokine genotype [J].
Arkwright, PD ;
Chase, JM ;
Babbage, S ;
Pravica, V ;
David, TJ ;
Hutchinson, IV .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (02) :281-+
[5]   HUMAN EPIDERMAL LANGERHANS CELLS EXPRESS THE HIGH-AFFINITY RECEPTOR FOR IMMUNOGLOBULIN-E (FC-EPSILON-RI) [J].
BIEBER, T ;
DELASALLE, H ;
WOLLENBERG, A ;
HAKIMI, J ;
CHIZZONITE, R ;
RING, J ;
HANAU, D ;
DELASALLE, C .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (05) :1285-1290
[6]   A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children [J].
Böttcher, MF ;
Hmani-Aifa, M ;
Lindström, A ;
Jenmalm, MC ;
Mai, XM ;
Nilsson, L ;
Zdolsek, HA ;
Björkstén, B ;
Söderkvist, P ;
Vaarala, O .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 114 (03) :561-567
[7]   Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB) [J].
Breuer, K ;
Wittmann, M ;
Bösche, B ;
Kapp, A ;
Werfel, T .
ALLERGY, 2000, 55 (06) :551-555
[8]   Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci [J].
Cookson, WOCM ;
Ubhi, B ;
Lawrence, R ;
Abecasis, GR ;
Walley, AJ ;
Cox, HE ;
Coleman, R ;
Leaves, NI ;
Trembath, RC ;
Moffatt, MF ;
Harper, JI .
NATURE GENETICS, 2001, 27 (04) :372-373
[9]  
Cox HE, 1998, BRIT J DERMATOL, V138, P182
[10]   The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema:: a European multicenter study [J].
Darsow, U ;
Laifaoui, J ;
Kerschenlohr, K ;
Wollenberg, A ;
Przybilla, B ;
Wüthrich, B ;
Borelli, S ;
Giusti, F ;
Seidenari, S ;
Drzimalla, K ;
Simon, D ;
Disch, R ;
Borelli, S ;
Devillers, ACA ;
Oranje, AP ;
De Raeve, L ;
Hachem, JP ;
Dangoisse, C ;
Blondeel, A ;
Song, M ;
Breuer, K ;
Wulf, A ;
Werfel, T ;
Roul, S ;
Taieb, A ;
Bolhaar, S ;
Bruijnzeel-Koomen, C ;
Brönnimann, M ;
Braathen, LR ;
Didierlaurent, A ;
André, C ;
Ring, J .
ALLERGY, 2004, 59 (12) :1318-1325