Improved yields of meta-amination and symmetrical and unsymmetrical diamination of benzenes

被引：15

作者：

Brown, GR ^{[1
]}

Foubister, AJ ^{[1
]}

Roberts, CA ^{[1
]}

Wells, SL ^{[1
]}

Wood, R ^{[1
]}

机构：

[1] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 23期

关键词：

amination; aryl halides; substituent effects;

D O I：

10.1016/S0040-4039(01)00582-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Much higher yields were found after shorter reaction times for the meta-substituted amination of benzenes in DMPU with microwave heating in a sealed tube (180 degreesC. 5 h). e.g. piperidine and m-fluorobenzonitrile 1 gave the m-substituted 3 in 92% yield. These modified reaction conditions also afforded a new synthesis of unsymmetrical diamines in > 80% yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3917 / 3919

页数：3

共 6 条

[1] Palladium-catalyzed amination of aryl dibromides with secondary amines: synthetic and mechanistic aspects [J].