Effects of some β-carboline alkaloids on intact Trypanosoma cruzi epimastigotes

被引：57

作者：

Rivas, P

Cassels, BK

Morello, A

Repetto, Y

机构：

[1] Univ Chile, Fac Sci, Dept Chem, Santiago 70086 7, Chile

[2] Univ Chile, Fac Med, Inst Biomed Sci, Program Clin Mol Pharmacol, Santiago 70086 7, Chile

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1999年 / 122卷 / 01期

关键词：

beta-carboline alkaloids; harmine; harmane; harmaline; Trypanosoma cruzi; Tulahuen strain; LQ strain; trypanosomicidal effect; trypanosomicidal drugs; parasiticidal drugs;

D O I：

10.1016/S0742-8413(98)10069-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several beta-carboline (9H-pyrido-[3,4-b]-indole) alkaloids were evaluated for in vitro trypanosomicidal activity against Trypanosoma cruzi epimastigotes belonging to two different strains (Tulahuen and LQ) showing different sensitivity to nifurtimox. Important differences were observed in the susceptibility of the parasites to these natural substances, with the relatively nifurtimox-resistant LQ strain showing greater sensitivity to the beta-carbolines. Respiratory chain inhibition appears to be a possible determinant of the trypanosomicidal activity of these compounds. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：27 / 31

页数：5

共 27 条

[1] In vivo potent antifilarial beta-carbolines [J].