Influence of ghrelin on food intake and energy homeostasis

被引：43

作者：

De Vriese, Carine ^{[1
]}

Delporte, Christine ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Fac Med, Lab Biol Chem & Nutr, B-1070 Brussels, Belgium

来源：

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | 2007年 / 10卷 / 05期

关键词：

appetite; energy homeostasis; food intake; ghrelin; obesity;

D O I：

10.1097/MCO.0b013e32829fb37c

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review The purpose of this review is to provide updated information on the role of ghrelin in food intake and energy homeostasis, and on its mechanism of action. Moreover, the potential of ghrelin as a target for drugs to treat cachexia and obesity will be discussed. Recent findings Whereas the effects of ghrelin in the regulation of appetite, food intake and energy homeostasis have been fairly well documented, the pathways responsible for the effects of ghrelin are now increasingly being understood. As a consequence, clinical applications of ghrelin are now being developed. Summary Ghrelin is an endogenous orexigenic peptide recently discovered in the stomach. Ghrelin is involved in short-term regulation of food intake since its plasma levels increase before meals and decrease strongly postprandially. Ghrelin is also involved in long-term body-weight regulation by inducing adiposity. Ghrelin might be useful for cachexia and obesity treatment.

引用

页码：615 / 619

页数：5

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