Changes in Myostatin Signaling in Non-Weight-Losing Cancer Patients

被引：60

作者：

Aversa, Zaira ^{[1
]}

Bonetto, Andrea ^{[2
]}

Penna, Fabio ^{[2
]}

Costelli, Paola ^{[2
]}

Di Rienzo, Gaetano ^{[3
]}

Lacitignola, Angelo ^{[3
]}

Baccino, Francesco M. ^{[2
]}

Ziparo, Vincenzo ^{[4
]}

Mercantini, Paolo ^{[4
]}

Rossi Fanelli, Filippo ^{[1
]}

Muscaritoli, Maurizio ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Clin Med, Rome, Italy

[2] Univ Turin, Dept Expt Med & Oncol, Turin, Italy

[3] Vito Fazzi Hosp, Lecce, Italy

[4] Univ Roma La Sapienza, Surg Unit A, Dept Surg, Fac Med 2, Rome, Italy

来源：

ANNALS OF SURGICAL ONCOLOGY | 2012年 / 19卷 / 04期

关键词：

MESSENGER-RNA LEVELS; SKELETAL-MUSCLE; LUNG-CANCER; CACHEXIA; UBIQUITIN; PATHWAY; GROWTH; PROTEIN; MICE; MECHANISMS;

D O I：

10.1245/s10434-011-1720-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. Myostatin is a negative regulator of skeletal muscle mass. We recently demonstrated that myostatin expression is upregulated in an experimental model of cancer cachexia, suggesting that modulations of this pathway might play a pathogenic role in cancer-related muscle wasting. The present study was designed to investigate whether myostatin signaling is modulated in the muscle of non-weight-losing (nWL) patients with lung and gastric cancer. Methods. Myostatin signaling was studied in muscle biopsies obtained during surgical procedure from nWL patients affected by gastric (n = 16) or lung (n = 17) cancer. Western blotting was applied to test both the total expression of myostatin and the expression of phosphorylated form of GSK-3beta and Smad2/3. Results. In patients with gastric cancer, the expression of both myostatin and phosphorylated GSK-3beta (p-GSK3 beta) were significantly increased. By contrast, in patients with lung cancer, myostatin levels were comparable to controls, whereas the expression of p-GSK3 beta significantly decreased in patients with disease stage III/IV. Conclusions. Myostatin signaling is altered in nWL cancer patients. Different tumor types may give rise to different patterns of molecular changes within the muscle, which occur even before cachexia becomes clinically apparent.

引用

页码：1350 / 1356

页数：7

共 31 条

[31] Induction of cachexia in mice by systemically administered myostatin
Zimmers, TA
Davies, MV
Koniaris, LG
Haynes, P
Esquela, AF
Tomkinson, KN
McPherron, AC
Wolfman, NM
Lee, SJ
[J]. SCIENCE, 2002, 296 (5572) : 1486 - 1488

← 1 2 3 4 →