Hsp47: A collagen-specific molecular chaperone

被引:190
作者
Nagata, K
机构
[1] Department of Cell Biology, Chest Disease Research Institute, Kyoto University, Kyoto 606-01, Sakyo-ku
关键词
D O I
10.1016/S0968-0004(06)80023-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hsp47 is a novel stress protein in the endoplasmic reticulum that binds specifically to various types of collagens and procollagens. Hsp47 transiently associates with procollagen and is involved in collagen processing and/or secretion under normal conditions. Under conditions of stress, Hsp47 is part of the quality control system for procollagen, including the prevention of the secretion of procollagen with abnormal conformation. In addition to its role as a molecular chaperone, Hsp47 synthesis always parallels that of collagen in developing tissues and various cell lines, and in collagen-related pathological conditions such as fibrosis.
引用
收藏
页码:23 / 26
页数:4
相关论文
共 29 条
  • [11] DISTINCT PATTERNS OF GLYCOSYLATION OF COLLIGIN, A COLLAGEN-BINDING GLYCOPROTEIN, AND SPARC (OSTEONECTIN), A SECRETED CA-2+-BINDING GLYCOPROTEIN - EVIDENCE FOR THE LOCALIZATION OF COLLIGIN IN THE ENDOPLASMIC-RETICULUM
    HUGHES, RC
    TAYLOR, A
    SAGE, H
    HOGAN, BLM
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 163 (01): : 57 - 65
  • [12] INHIBITION OF PROCOLLAGEN-I DEGRADATION BY COLLIGIN - A COLLAGEN-BINDING SERPIN
    JAIN, N
    BRICKENDEN, A
    BALL, EH
    SANWAL, BD
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1994, 314 (01) : 23 - 30
  • [13] KURKINEN M, 1984, J BIOL CHEM, V259, P5915
  • [14] Mayne R., 1987, Structure and Function of Collagen Types, DOI 10.1016/B978-0-12-481280-2.X5001-6
  • [15] DISTRIBUTION OF THE COLLAGEN BINDING HEAT-SHOCK PROTEIN IN CHICKEN TISSUES
    MIYAISHI, O
    SAKATA, K
    MATSUYAMA, M
    SAGA, S
    [J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1992, 40 (07) : 1021 - 1029
  • [16] NAGATA K, 1986, J BIOL CHEM, V261, P7531
  • [17] A MAJOR COLLAGEN-BINDING PROTEIN OF CHICK-EMBRYO FIBROBLASTS IS A NOVEL HEAT-SHOCK PROTEIN
    NAGATA, K
    SAGA, S
    YAMADA, KM
    [J]. JOURNAL OF CELL BIOLOGY, 1986, 103 (01) : 223 - 229
  • [18] NAKAI A, 1990, J BIOL CHEM, V265, P992
  • [19] INVOLVEMENT OF THE STRESS PROTEIN HSP47 IN PROCOLLAGEN PROCESSING IN THE ENDOPLASMIC-RETICULUM
    NAKAI, A
    SATOH, M
    HIRAYOSHI, K
    NAGATA, K
    [J]. JOURNAL OF CELL BIOLOGY, 1992, 117 (04) : 903 - 914
  • [20] NATSUME T, 1994, J BIOL CHEM, V269, P31224