Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia

被引：33

作者：

van de Ven, Annick A. J. M. ^{[1
]}

Douma, Jan Willem ^{[2
]}

Rademaker, Carin ^{[2
]}

van Loon, Anton M. ^{[3
]}

Wensing, Annemarie M. J. ^{[3
]}

Boelens, Jaap-Jan ^{[1
]}

Sanders, Elisabeth A. M. ^{[1
]}

van Montfrans, Joris M. ^{[1
]}

机构：

[1] Wilhelmina Childrens Hosp, Univ Med Ctr Utrecht, Dept Pediat Immunol & Infect Dis, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Clin Pharm, Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Dept Virol, Utrecht, Netherlands

来源：

ANTIVIRAL THERAPY | 2011年 / 16卷 / 04期

关键词：

ORAL PLECONARIL; INFECTIONS; EFFICACY; TRIALS; ADULTS;

D O I：

10.3851/IMP1792

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immuno-compromised host.

引用

页码：611 / 614

页数：4

共 19 条

[1] Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution and effect of food [J].

Abdel-Rahman, SM ;

Kearns, GL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (10) :2706-2709

[2] Evolution of poliovirus type I during 5.5 years of prolonged enteral replication in an immunodeficient patient [J].

Bellmunt, A ;

May, G ;

Zell, R ;

Pring-Åkerblom, P ;

Verhagen, W ;

Heim, A .

VIROLOGY, 1999, 265 (02) :178-184

[3] Common variable immunodeficiency disorders: division into distinct clinical phenotypes [J].

Chapel, Helen ;

Lucas, Mary ;

Lee, Martin ;

Bjorkander, Janne ;

Webster, David ;

Grimbacher, Bodo ;

Fieschi, Claire ;

Thon, Vojtech ;

Abedi, Mohammad R. ;

Hammarstrom, Lennart .

BLOOD, 2008, 112 (02) :277-286

[4]

European Society for Immunodeficiencies, 2005, DIAGN CRIT PID COMM

[5] Enteroviral infections in primary immunodeficiency (PID): A survey of morbidity and mortality [J].

Halliday, E ;

Winkelstein, J ;

Webster, ADB .

JOURNAL OF INFECTION, 2003, 46 (01) :1-8

[6]

Hayden FG, 2002, ANTIVIR THER, V7, P53

[7] Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: Results of 2 double-blind, randomized, placebo-controlled trials [J].

Hayden, FG ;

Herrington, DT ;

Coats, TL ;

Kim, K ;

Cooper, EC ;

Villano, SA ;

Liu, SY ;

Hudson, S ;

Pevear, DC ;

Collett, M ;

McKinlay, M .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (12) :1523-1532

[8] A DISTINCT PICORNAVIRUS GROUP IDENTIFIED BY SEQUENCE-ANALYSIS [J].

HYYPIA, T ;

HORSNELL, C ;

MAARONEN, M ;

KHAN, M ;

KALKKINEN, N ;

AUVINEN, P ;

KINNUNEN, L ;

STANWAY, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8847-8851

[9] Polio - New challenges in 2006 [J].

Katz, Samuel L. .

JOURNAL OF CLINICAL VIROLOGY, 2006, 36 (03) :163-165

[10] Specific RT-PCR procedure for the detection of human parechovirus type 1 genome in clinical samples [J].

Legay, V ;

Chomel, JJ ;

Lina, B .

JOURNAL OF VIROLOGICAL METHODS, 2002, 102 (1-2) :157-160

← 1 2 →