A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity

被引：60

作者：

Wang, Dao-Ping ^{[2
,3
]}

Lou, Hua-Yong ^{[2
,3
,5
]}

Huang, Lan ^{[2
,3
,4
]}

Hao, Xiao-Jiang ^{[2
,3
]}

Liang, Guang-Yi ^{[2
,3
,5
]}

Yang, Zai-Chang ^{[1
]}

Pan, Wei-Dong ^{[2
,3
]}

机构：

[1] Guizhou Univ, Coll Chem Engn, Guiyang 550003, Peoples R China

[2] Chinese Acad Sci, Guiyang 550002, Peoples R China

[3] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China

[4] Guizhou Univ, Coll Life Scinence, Guiyang 550025, Peoples R China

[5] Guiyang Coll Tradit Chinese Med, Guiyang 550002, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 13期

关键词：

Aconitum carmichaeli Debx; Guiwuline; Franchetine type C-19-diterpenoid alkaloid; Analgesic activity; ALKALOIDS;

D O I：

10.1016/j.bmcl.2012.04.132

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Further investigation on the phytochemistry of the plant Aconitum carmichaeli Debx. led to isolate a new franchetine type C-19-diterpenoid alkaloid, guiwuline 1. Its structure was established on the basis of the spectroscopic data (1D and 2D NMR, HRESIMS, UV, IR). In mouse hot-plate test and acute toxicity assay, compound 1 exhibited potential analgesic activity (ED50, 15 mg/kg) and showed little toxicity to mice (LD50, 500 mg/kg). The results indicate that compound 1 may be used as a lead molecule to develop novel analgesic agents. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4444 / 4446

页数：3

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