BACTERIAL CYTOTOXICITY OF THE SILVER NANOPARTICLE RELATED TO PHYSICOCHEMICAL METRICS AND AGGLOMERATION PROPERTIES

被引：121

作者：

Bae, Eunjoo ^{[1
]}

Park, Hee-Jin ^{[1
]}

Lee, Jeongjin ^{[1
]}

Kim, Younghun ^{[2
]}

Yoon, Jeyong ^{[1
]}

Park, Kwangsik ^{[3
]}

Choi, Kyunghee ^{[4
]}

Yi, Jongheop ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151742, South Korea

[2] Kwangwoon Univ, Dept Chem Engn, Seoul 139701, South Korea

[3] Dongduk Womens Univ, Coll Pharm, Seoul 136714, South Korea

[4] Natl Inst Environm Res, Inchon 404708, South Korea

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2010年 / 29卷 / 10期

关键词：

Silver nanoparticles; Agglomeration; Nanomaterial; Toxicity; Escherichia coli; ANTIBACTERIAL ACTIVITY; TOXICITY; PARTICLES; AGGREGATION; AG+;

D O I：

10.1002/etc.278

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Silver particles are used in various consumer products due to their positive effects, which include sterilization and antibacterial properties. However, it has been reported that silver nanoparticles (AgNPs) have strongly acute toxic effects on various cells. Therefore, the cytotoxicity of AgNPs was investigated, using Escherichia coli as a model organism, from the standpoint of three key metrics (ionic ratio, size, and agglomeration) that are the most relevant physicochemical properties. The findings indicated that cytotoxicity is depressed by the agglomeration of AgNPs. The order of toxic sensitivity was as follows: total Ag concentration > ionic ratio > size, the order of which was inversely related to the extent of agglomeration. Environ. Toxicol. Chem. 2010;29:2154-2160. (C) 2010 SETAC

引用

页码：2154 / 2160

页数：7

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