Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice

被引：97

作者：

Inoue, M

Kobayashi, M

Kozaki, S

Zimmer, A

Ueda, H ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol & Neurosci, Nagasaki 8528521, Japan

[2] Osaka Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Suita, Osaka 565, Japan

[3] Univ Osaka Prefecture, Coll Agr, Dept Vet Sci, Sakai, Osaka 593, Japan

[4] NIMH, Genet Sect, Bethesda, MD 20892 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 18期

关键词：

D O I：

10.1073/pnas.95.18.10949

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have studied the in vivo signaling mechanisms involved in nociceptin/orphanin FQ (Noci)-induced pain responses by using a flexor-reflex paradigm. Noci was 10,000 times more potent than substance P (SP) in eliciting flexor responses after intraplantar injection into the hind limb of mice, but the action of Noci seems to be mediated by SP. Mice pretreated with an NK1 tachykinin receptor antagonist or capsaicin, or mice with a targeted disruption of the tachykinin 1 gene no longer respond to Noci. The action of Noci appears to be mediated by the Noci receptor, a pertussis toxin-sensitive G protein-coupled receptor that stimulates inositol trisphosphate receptor and Ca2+ influx. These findings suggest that Noci indirectly stimulates nerve endings of nociceptive primary afferent neurons through a local SP release.

引用

页码：10949 / 10953

页数：5

共 38 条

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