Hypoxia and chronic lung disease

被引:121
作者
Tuder, Rubin M.
Yun, Jeong H.
Bhunia, Anil
Fijalkowska, Iwona
机构
[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Div Cardiopulm Pathol, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, Baltimore, MD 21205 USA
来源
JOURNAL OF MOLECULAR MEDICINE-JMM | 2007年 / 85卷 / 12期
关键词
hypoxia; lung; pathology; HIF;
D O I
10.1007/s00109-007-0280-4
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The lung is both the conduit for oxygen uptake and is also affected by hypoxia and hypoxia signaling. Decreased ventilatory drive, airway obstructive processes, intra-alveolar exudates, septal thickening by edema, inflammation, fibrosis, or damage to alveolar capillaries will all interpose a significant and potentially life-threatening barrier to proper oxygenation, therefore enhancing the alveolar/arterial pO(2) gradient. These processes result in decreased blood and tissue oxygenation. This review addresses the relationship of hypoxia with lung development and with lung diseases. We particularly focus on molecular mechanisms underlying hypoxia-driven physiological and pathophysiological lung processes, specifically in the infant lung, pulmonary hypertension, and chronic obstructive pulmonary disease.
引用
收藏
页码:1317 / 1324
页数:8
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