Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain

被引：88

作者：

Hanus, L

Avraham, Y

Ben-Shushan, D

Zolotarev, O

Berry, EM

Mechoulam, R

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med, Dept Human Nutr & Metab, IL-91120 Jerusalem, Israel

来源：

BRAIN RESEARCH | 2003年 / 983卷 / 1-2期

基金：

以色列科学基金会;

关键词：

2-arachidonoyl glycerol; 2-AG; cannabinoid system; diet restriction; endocannabinoid; brain; hippocampus; hypothalamus;

D O I：

10.1016/S0006-8993(03)03046-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

2-Arachidonoyl glycerol (2-AG) levels in whole mouse brain and two of its regions-hippocampus and hypothalamus-were determined after diet restriction (between 60 and 40%) lasting 12 days. The diet restriction lowered the level of 2-AG, which in the hypothalamus depended on the severity of the diet restriction, while the level in the hippocampus was not dependent on the diet regimen. As these observations differ from previously published data showing elevation of 2-AG levels in rat brain after 24 h of severe food restriction, we measured 2-AG levels in whole mouse,brain after a comparable period of full starvation (fasting). We confirmed the elevation of 2-AG levels. It seems possible that these time-dependent variations of 2-AG levels may be of importance as a general coping strategy by animals during periods of starvation. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：144 / 151

页数：8

共 36 条

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