A new diastereoselective aza-allyl conjugate addition-Michael addition-ring closure reaction sequence and its application in the construction of six contiguous stereogenic centres

被引：19

作者：

Koutsaplis, Magdaline

Andrews, Philip C. ^{[1
]}

Bull, Steven D.

Duggan, Peter J.

Fraser, Benjamin H.

Jensen, Paul

机构：

[1] Monash Univ, Sch Chem, Melbourne, Vic 3800, Australia

[2] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[3] CSIRO Mol Hlth & Technol, Melbourne, Vic 3169, Australia

[4] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 34期

关键词：

D O I：

10.1039/b707707f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of the sodium anion of (S)-N-(alpha-methylbenzyl)allylamine with two equivalents of tert-butyl cinnamate results in a remarkable tandem aza-allyl conjugate addition-Michael addition-ring closure reaction, resulting in a chiral aminocyclohexane containing six new vicinal stereogenic centres with excellent levels of stereocontrol.

引用

收藏

页码：3580 / 3582

页数：3

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