Asymmetric synthesis of homochiral Baylis-Hillman products employing (R)-N-methyl-N-α-methylbenzyl amide

被引：21

作者：

Davies, SG ^{[1
]}

Smethurst, CAP ^{[1
]}

Smith, AD ^{[1
]}

Smyth, GD ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0957-4166(00)00224-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The conjugate addition of (R)-N-methyl-N-alpha-methylbenzyl amide to tert-butyl cinnamate followed by an asymmetric aldol reaction and subsequent N-oxidation/Cope elimination affords beta-substituted homochiral Baylis-Hillman products in good yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2437 / 2441

页数：5

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