Biorefineries for the production of top building block chemicals and their derivatives

被引：375

作者：

Choi, Sol ^{[1
,2
]}

Song, Chan Woo ^{[1
]}

Shin, Jae Ho ^{[1
]}

Lee, Sang Yup ^{[1
,2
,3
,4
]}

机构：

[1] Korea Adv Inst Sci & Technol, Ctr Syst & Synthet Biotechnol, Inst BioCentury,Metab & Biomol Engn, Dept Chem & Biomol Engn,Natl Res Lab,Plus Program, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, BioProc Engn Res Ctr, Taejon 305701, South Korea

[3] Korea Adv Inst Sci & Technol, Biolnformat Res Ctr, Taejon 305701, South Korea

[4] Tech Univ Denmark, Novo Nordisk Fdn, Ctr Biosustainabil, Horsholm, Denmark

来源：

METABOLIC ENGINEERING | 2015年 / 28卷

基金：

新加坡国家研究基金会;

关键词：

Platform chemicals; Biorefinery; Commercialization; DOE report; SUCCINIC ACID PRODUCTION; ESCHERICHIA-COLI; 3-HYDROXYPROPIONIC ACID; LACTIC-ACID; MANNHEIMIA-SUCCINICIPRODUCENS; CORYNEBACTERIUM-GLUTAMICUM; KLEBSIELLA-PNEUMONIAE; RENEWABLE RESOURCES; GAMMA-VALEROLACTONE; XYLITOL PRODUCTION;

D O I：

10.1016/j.ymben.2014.12.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Due to the growing concerns on the climate change and sustainability on petrochemical resources, DOE selected and announced the bio-basecl top 12 building blocks and discussed the needs for developing biorefinery technologies to replace the current petroleum based industry in 2004. Over the last 10 years after its announcement, many studies have been performed for the development of efficient technologies for the bio-based production of these chemicals and derivatives. Now, ten chemicals among these Lop 12 chemicals, excluding the L-aspartic acid and 3-hydroxybutyrolactone, have already been commercialized or are close to commercialization. In this paper, we review the current status of biorefinery development for the production of these platform chemicals and their derivatives. In addition, current technological advances on industrial strain development for the production of platform chemicals using micro-organisms will be covered in detail with case studies on succinic acid and 3-hydroxypropionic acid as examples. (C) 2015 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

引用

页码：223 / 239

页数：17

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