Human antisense genes have unusually short introns: evidence for selection for rapid transcription

被引：54

作者：

Chen, JJ

Sun, M

Hurst, LD

Carmichael, GG

Rowley, JD

机构：

[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[2] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[3] Univ Connecticut, Hlth Ctr, Dept Genet & Dev Biol, Farmington, CT 06030 USA

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 04期

关键词：

D O I：

10.1016/j.tig.2005.02.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We suggest that small introns are favored in genes requiring a minimal response time ('nimble' genes), and that antisense genes might be prime candidates for such nimble genes. In this article, we show that antisense genes have significantly shorter introns than all other gene categories, which supports our proposal that the short introns of antisense genes might be functionally important and integrally related to their potential role in efficient gene regulation.

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页码：203 / 207

页数：5

相关论文

共 20 条

[1] Switching on and off with RNA [J].

Altuvia, S ;

Wagner, EGH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :9824-9826

[2] Antisense starts making more sense [J].

Carmichael, GG .

NATURE BIOTECHNOLOGY, 2003, 21 (04) :371-372

[3] Selection for short introns in highly expressed genes [J].

Castillo-Davis, CI ;

Mekhedov, SL ;

Hartl, DL ;

Koonin, EV ;

Kondrashov, FA .

NATURE GENETICS, 2002, 31 (04) :415-418

[4] Over 20% of human transcripts might form sense-antisense pairs [J].

Chen, JJ ;

Sun, M ;

Kent, WJ ;

Huang, XQ ;

Xie, HQ ;

Wang, WQ ;

Zhou, GL ;

Shi, RZ ;

Rowley, JD .

NUCLEIC ACIDS RESEARCH, 2004, 32 (16) :4812-4820

[5] Non-coding RNA genes and the modern RNA world [J].

Eddy, SR .

NATURE REVIEWS GENETICS, 2001, 2 (12) :919-929

[6] Computational Genomics of noncoding RNA genes [J].

Eddy, SR .

CELL, 2002, 109 (02) :137-140

[7] Regulatory RNAs [J].

Erdmann, VA ;

Barciszewska, MZ ;

Hochberg, A ;

de Groot, N ;

Barciszewski, J .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2001, 58 (07) :960-977

[8] Overlapping antisense transcription in the human genome [J].

Fahey, ME ;

Moore, TF ;

Higgins, DG .

COMPARATIVE AND FUNCTIONAL GENOMICS, 2002, 3 (03) :244-253

[9] DIFFERENTIAL ANTISENSE TRANSCRIPTION FROM THE DICTYOSTELIUM EB4 GENE LOCUS - IMPLICATIONS ON ANTISENSE-MEDIATED REGULATION OF MESSENGER-RNA STABILITY [J].

HILDEBRANDT, M ;

NELLEN, W .

CELL, 1992, 69 (01) :197-204

[10] Imprinted genes have few and small introns [J].

Hurst, LD ;

McVean, G ;

Moore, T .

NATURE GENETICS, 1996, 12 (03) :234-237