Human antisense genes have unusually short introns: evidence for selection for rapid transcription

被引：54

作者：

Chen, JJ

Sun, M

Hurst, LD

Carmichael, GG

Rowley, JD

机构：

[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[2] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[3] Univ Connecticut, Hlth Ctr, Dept Genet & Dev Biol, Farmington, CT 06030 USA

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 04期

关键词：

D O I：

10.1016/j.tig.2005.02.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We suggest that small introns are favored in genes requiring a minimal response time ('nimble' genes), and that antisense genes might be prime candidates for such nimble genes. In this article, we show that antisense genes have significantly shorter introns than all other gene categories, which supports our proposal that the short introns of antisense genes might be functionally important and integrally related to their potential role in efficient gene regulation.

引用

收藏

页码：203 / 207

页数：5

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