Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as Positive T1 Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchyrnal Stem Cells

被引：490

作者：

Kim, Taeho ^{[1
,2
,3
]}

Momin, Eric ^{[4
]}

Choi, Jonghoon ^{[2
,3
]}

Yuan, Kristy ^{[4
]}

Zaidi, Hasan ^{[4
]}

Kim, Jaeyun ^{[1
,2
,3
]}

Park, Mihyun ^{[1
]}

Lee, Nohyun ^{[1
]}

McMahon, Michael T. ^{[2
,5
]}

Quinones-Hinojosa, Alfredo ^{[4
]}

Bulte, Jeff W. M. ^{[2
,3
,6
,7
]}

Hyeon, Taeghwan ^{[1
]}

Gilad, Assaf A. ^{[2
,3
,5
]}

机构：

[1] Seoul Natl Univ, World Class Univ Program Chem Convergence Energy, Natl Creat Res Initiat Ctr Oxide Nanocrystalline, Seoul 151744, South Korea

[2] Johns Hopkins Univ Hosp, Sch Med, Div MR Res, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Cellular Imaging Sect, Inst Cell Engn, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol Surg, Baltimore, MD 21205 USA

[5] FM Kirby Res Ctr Funct Brain Imaging, Kennedy Krieger Inst, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, Dept Chem & Biomol Engn, Baltimore, MD 21205 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

MAGNETIC-RESONANCE TRACKING; IN-VIVO TRACKING; QUANTUM DOTS; SHELL; SEMICONDUCTOR; NANOCRYSTALS; MIGRATION; DESIGN; CORE; DRUG;

D O I：

10.1021/ja1084095

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Mesoporous silica-coated hollow manganese oxide (HIVInO@ mSiO(2)) nanoparticles were developed as a novel T-1 magnetic resonance imaging (MRI) contrast agent. We hypothesized that the mesoporous structure of the nanopartide shell enables optimal access of water molecules to the magnetic core, and consequently, an effective longitudinal (R-1) relaxation enhancement of water protons, which value was measured to be 0.99 (mM(-1) s(-1)) at 11.7 T. Adipose-derived mesenchymal stem cells (MSCs) were efficiently labeled using electroporation, with much shorter T-1 values as compared to direct incubation without electroporation, which was also evidenced by signal enhancement on T-1-weighted MR images in vitro. Intracranial grafting of HMnO@mSiO(2)-labeled MSCs enabled serial MR monitoring of cell transplants over 14 days. These novel nanopartides may extend the arsenal of currently available nanoparticie MR contrast agents by providing positive contrast on T-1-weighted images at high magnetic field strengths.

引用

页码：2955 / 2961

页数：7

共 76 条

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Gd-loaded liposomes as T1, susceptibility, and CEST agents, all in one [J].