New small-molecule synthetic antimycobacterials

被引:175
作者
Ballell, L
Field, RA
Duncan, K
Young, RJ
机构
[1] Univ E Anglia, Sch Chem Sci & Pharm, Ctr Carbohydrate Chem, Norwich NR4 7TJ, Norfolk, England
[2] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England
基金
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词
D O I
10.1128/AAC.49.6.2153-2163.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
引用
收藏
页码:2153 / 2163
页数:11
相关论文
共 117 条
[31]   SYNTHESIS AND ANTI-BACTERIAL ACTIVITY OF SOME 3-[(ALKYLTHIO)METHYL]QUINOXALINE 1-OXIDE DERIVATIVES [J].
DIRLAM, JP ;
PRESSLITZ, JE ;
WILLIAMS, BJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (08) :1122-1126
[32]   Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups [J].
Dong, YX ;
Matile, H ;
Chollet, J ;
Kaminsky, R ;
Wood, JK ;
Vennerstrom, JL .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (08) :1477-1480
[33]   A protein kinase inhibitor as an antimycobacterial agent [J].
Drews, SJ ;
Hung, FM ;
Av-Gay, Y .
FEMS MICROBIOLOGY LETTERS, 2001, 205 (02) :369-374
[34]   Prospects for new antitubercular drugs [J].
Duncan, K ;
Barry, CE .
CURRENT OPINION IN MICROBIOLOGY, 2004, 7 (05) :460-465
[35]   Identification and validation of novel drug targets in tuberculosis [J].
Duncan, K .
CURRENT PHARMACEUTICAL DESIGN, 2004, 10 (26) :3185-3194
[36]   Progress in TB drug development and what is still needed [J].
Duncan, K .
TUBERCULOSIS, 2003, 83 (1-3) :201-207
[37]   Phenylthio-derivatives of α-methylene-γ-lactones as pro-drugs of cytotoxic agents [J].
Fardella, G ;
Barbetti, P ;
Grandolini, G ;
Chiappini, I ;
Ambrogi, V ;
Scarcia, V ;
Candiani, AF .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1999, 34 (06) :515-523
[38]   Similarity approach to QSAR -: Application to antimycobacterial benzoxazines [J].
Gallegos, A ;
Carbó-Dorca, R ;
Ponec, R ;
Waisser, K .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2004, 269 (01) :51-60
[39]   The resurgence of disease: social and historical perspectives on the 'new' tuberculosis [J].
Gandy, M ;
Zumla, A .
SOCIAL SCIENCE & MEDICINE, 2002, 55 (03) :385-396
[40]   Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxide [J].
Ganley, B ;
Chowdhury, G ;
Bhansali, J ;
Daniels, JS ;
Gates, KS .
BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (09) :2395-2401