XIAP, the guardian angel

被引：233

作者：

Holcik, M

Korneluk, RG

机构：

[1] Childrens Hosp Eastern Ontario, Res Inst, Ottawa, ON K1H 8L1, Canada

[2] AEgera Oncol Inc, Ottawa, ON K1H 8L1, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 07期

关键词：

D O I：

10.1038/35080103

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Controlling the activity of caspases is essential for the appropriate execution of cell death and the regulation of cell survival, One cellular inhibitor of apoptosis, XIAP, has emerged as a crucial regulator of caspases, and is itself subject to complex negative regulation.

引用

收藏

页码：550 / 556

页数：7

相关论文

共 35 条

[1]

Bangs P, 2000, DEV DYNAM, V218, P68, DOI 10.1002/(SICI)1097-0177(200005)218:1<68::AID-DVDY6>3.0.CO

[2]

2-9

[3] Recruitment, activation and retention of caspases-9 and-3 by Apaf-1 apoptosome and associated XIAP complexes [J].

Bratton, SB ;

Walker, G ;

Srinivasula, SM ;

Sun, XM ;

Butterworth, M ;

Alnemri, ES ;

Cohen, GM .

EMBO JOURNAL, 2001, 20 (05) :998-1009

[4] Structural basis of caspase-7 inhibition by XIAP [J].

Chai, JJ ;

Shiozaki, E ;

Srinivasula, SM ;

Wu, Q ;

Dataa, P ;

Alnemri, ES ;

Shi, YG .

CELL, 2001, 104 (05) :769-780

[5] Structural and biochemical basis of apoptotic activation by Smac/DIABLO [J].

Chai, JJ ;

Du, CY ;

Wu, JW ;

Kyin, S ;

Wang, XD ;

Shi, YG .

NATURE, 2000, 406 (6798) :855-862

[6] IAP family proteins - suppressors of apoptosis [J].

Deveraux, QL ;

Reed, TC .

GENES & DEVELOPMENT, 1999, 13 (03) :239-252

[7] Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases [J].

Deveraux, QL ;

Leo, E ;

Stennicke, HR ;

Welsh, K ;

Salvesen, GS ;

Reed, JC .

EMBO JOURNAL, 1999, 18 (19) :5242-5251

[8] Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition [J].

Du, CY ;

Fang, M ;

Li, YC ;

Li, L ;

Wang, XD .

CELL, 2000, 102 (01) :33-42

[9] Caspase inhibitors [J].

Ekert, PG ;

Silke, J ;

Vaux, DL .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (11) :1081-1086

[10] Caspases disrupt the nuclear-cytoplasmic barrier [J].

Faleiro, L ;

Lazebnik, Y .

JOURNAL OF CELL BIOLOGY, 2000, 151 (05) :951-959

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