Trigoxyphins A-G: Diterpenes from Trigonostemon xyphophylloides

被引：48

作者：

Lin, Bing-Dong ^{[1
]}

Han, Mei-Ling ^{[1
]}

Ji, Yin-Chun ^{[1
]}

Chen, Hua-Dong ^{[1
]}

Yang, Sheng-Ping ^{[1
]}

Zhang, Sheng ^{[1
]}

Geng, Mei-Yu ^{[1
]}

Yue, Jian-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 07期

关键词：

REIDIOIDES; DAPHNANE; REDIOCIDE; APOPTOSIS; ASSAY;

D O I：

10.1021/np100320h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new oxygenated daphnane-type diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xphophylloides. Their structures were established using spectroscopic methods. Compounds 1 and 2 exhibited strong cytotoxic activity against HL60 (IC(50): 0.27 and 0.49 mu M) and A549 (IC(50): 7.5 and 4.9 mu M) tumor cell lines, respectively.

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收藏

页码：1301 / 1305

页数：5

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