Thermotrp channels and beyond: Mechanisms of temperature sensation

被引：612

作者：

Patapoutian, A ^{[1
]}

Peier, AM

Story, GM

Viswanath, V

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2003年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrn1141

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We possess an acute sense of temperature. Most of us seek shade on a hot summer day, prefer a warm shower to a cold one, and enjoy red wines served at a temperature of 15-18degreesC. Thermosensation not only affects our comfort, but is also essential for the survival of most organisms. We are now beginning to uncover the molecular identity of proteins that confer thermosensation. The thermoTRPs, a subset of transient receptor potential ion channels are activated by distinct physiological temperatures, and are involved in converting thermal information into chemical and electrical signals within the sensory nervous system.

引用

页码：529 / 539

页数：11

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