Drug release behaviors of a pH sensitive semi-interpenetrating polymer network hydrogel composed of poly(vinyl alcohol) and star poly[2-(dimethylamino)ethyl methacrylate]

被引：112

作者：

Wu, Wei ^{[1
]}

Liu, Jing ^{[1
]}

Cao, Shuqin ^{[1
]}

Tan, Hong ^{[1
]}

Li, Jianshu ^{[1
]}

Xu, Fujian ^{[2
]}

Zhang, Xiao ^{[1
]}

机构：

[1] Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China

[2] Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing 100029, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2011年 / 416卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Semi-interpenetrating polymer network hydrogel; Star polymer; PH-sensitive; Swelling behaviors; Drug release; ACID) IPN HYDROGELS; SWELLING BEHAVIOR; MORPHOLOGY; PNIPAAM; CORE;

D O I：

10.1016/j.ijpharm.2011.06.015

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

A series of pH sensitive semi-interpenetrating polymer network (semi-IPN) structural hydrogels composed of poly(vinyl alcohol) (PVA) and 21-arm star poly[2-(dimethylamino)ethyl methacrylate] (star PDMAEMA) with different molecular weight were prepared. Riboflavin was used as a model drug to evaluate the drug loading capacities and drug release behaviors of the semi-IPN structural hydrogels. The molecular weight of the star PDMAEMA polymers was calculated by GPC, and the formation of semi-IPN structure was confirmed by FTIR and SEM. It was found that the molecular weight of star PDMAEMA has significant effect on the structure, swelling ratio and drug release behaviors of the semi-IPN hydrogel at different pH conditions. The results suggested that the PVA/star PDMAEMA-50,000 hydrogel exhibited highest swelling ratio and drug loading capacity. The pH-sensitive semi-IPN hydrogel based on star PDMAEMA could be a promising drug delivery system due to the controllable porous structure. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：104 / 109

页数：6

共 35 条

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Evaluation of a pH-sensitive semi-interpenetrating polymer network for control of GI drug delivery [J].