Microbial transformation of pyrethrosin

被引：14

作者：

Galal, AM ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 08期

关键词：

D O I：

10.1021/np0100082

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Microbial transformation of the germacranolide pyrethrosin (1) using Rhizopus nigricans NRRL 1477 has resulted in the isolation of 6 alpha -acetoxy-1 beta ,4 alpha -dihydroxy-5,7 alphaH,8 betaH-eudesm-11 beta ,13-dihydro-8,12-olide (5), a new eudesmanolide-type metabolite, in addition to the previously reported eudesmanolides: 2, 3, 4, and 6. The structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses. The isolated metabolites exhibited cytotoxic, antifungal, and antiprotozoal activities.

引用

页码：1098 / 1099

页数：2

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