Bacterial effector interplay: a new way to view effector function

被引:41
作者
Shames, Stephanie R. [1 ,2 ]
Finlay, B. Brett [1 ,2 ,3 ]
机构
[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada
[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada
[3] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z4, Canada
基金
加拿大健康研究院;
关键词
bacterial pathogen; effector; effector interplay; regulation; type III secretion system; type IV secretion system; ENTEROPATHOGENIC ESCHERICHIA-COLI; III SECRETION SYSTEM; ACTIVITY FACTOR CPAF; NF-KAPPA-B; LEGIONELLA-PNEUMOPHILA; HOST MITOCHONDRIA; EPITHELIAL-CELLS; ESPF EFFECTOR; PROTEASE; PROTEINS;
D O I
10.1016/j.tim.2012.02.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bacterial pathogens are dependent on virulence factors to efficiently colonize and propagate within their hosts. Many Gram-negative bacterial pathogens rely on specialized proteinaceous secretion systems that inject virulence factors, termed effectors, directly into host cells. These bacterial effector proteins perform various functions within host cells; however, regulation of their function within the host cell is highly enigmatic. It is becoming increasingly apparent that many of these effectors directly influence and regulate each other and their mechanisms within the host cell. We discuss the emerging theme of bacterial effector interplay impacting infection and the importance of investigating this topic.
引用
收藏
页码:214 / 219
页数:6
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