共 62 条
Bacterial effector interplay: a new way to view effector function
被引:41
作者:

Shames, Stephanie R.
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h-index: 0
机构:
Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada
Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

Finlay, B. Brett
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h-index: 0
机构:
Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada
Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada
Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada
机构:
[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada
[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada
[3] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z4, Canada
基金:
加拿大健康研究院;
关键词:
bacterial pathogen;
effector;
effector interplay;
regulation;
type III secretion system;
type IV secretion system;
ENTEROPATHOGENIC ESCHERICHIA-COLI;
III SECRETION SYSTEM;
ACTIVITY FACTOR CPAF;
NF-KAPPA-B;
LEGIONELLA-PNEUMOPHILA;
HOST MITOCHONDRIA;
EPITHELIAL-CELLS;
ESPF EFFECTOR;
PROTEASE;
PROTEINS;
D O I:
10.1016/j.tim.2012.02.007
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Bacterial pathogens are dependent on virulence factors to efficiently colonize and propagate within their hosts. Many Gram-negative bacterial pathogens rely on specialized proteinaceous secretion systems that inject virulence factors, termed effectors, directly into host cells. These bacterial effector proteins perform various functions within host cells; however, regulation of their function within the host cell is highly enigmatic. It is becoming increasingly apparent that many of these effectors directly influence and regulate each other and their mechanisms within the host cell. We discuss the emerging theme of bacterial effector interplay impacting infection and the importance of investigating this topic.
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页码:214 / 219
页数:6
相关论文
共 62 条
[31]
Agrobacterium Counteracts Host-Induced Degradation of Its Effector F-Box Protein
[J].
Magori, Shimpei
;
Citovsky, Vitaly
.
SCIENCE SIGNALING,
2011, 4 (195)

Magori, Shimpei
论文数: 0 引用数: 0
h-index: 0
机构:
SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA

Citovsky, Vitaly
论文数: 0 引用数: 0
h-index: 0
机构:
SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA
[32]
Real-time analysis of effector translocation by the type III secretion system of enteropathogenic Escherichia coli
[J].
Mills, Erez
;
Baruch, Kobi
;
Charpentier, Xavier
;
Kobi, Simi
;
Rosenshine, Ilan
.
CELL HOST & MICROBE,
2008, 3 (02)
:104-113

Mills, Erez
论文数: 0 引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel

Baruch, Kobi
论文数: 0 引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel

Charpentier, Xavier
论文数: 0 引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel

Kobi, Simi
论文数: 0 引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel

Rosenshine, Ilan
论文数: 0 引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91904 Jerusalem, Israel
[33]
Proteasome-independent Degradation of Canonical NFκB Complex Components by the NleC Protein of Pathogenic Escherichia coli
[J].
Muehlen, Sabrina
;
Ruchaud-Sparagano, Marie-Helene
;
Kenny, Brendan
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2011, 286 (07)
:5100-5107

论文数: 引用数:
h-index:
机构:

Ruchaud-Sparagano, Marie-Helene
论文数: 0 引用数: 0
h-index: 0
机构:
Newcastle Univ, Inst Cell & Mol Biosci, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Newcastle Univ, Inst Cell & Mol Biosci, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Kenny, Brendan
论文数: 0 引用数: 0
h-index: 0
机构:
Newcastle Univ, Inst Cell & Mol Biosci, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Newcastle Univ, Inst Cell & Mol Biosci, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[34]
The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b
[J].
Mueller, Matthias P.
;
Peters, Heide
;
Bluemer, Julia
;
Blankenfeldt, Wulf
;
Goody, Roger S.
;
Itzen, Aymelt
.
SCIENCE,
2010, 329 (5994)
:946-949

Mueller, Matthias P.
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany

Peters, Heide
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany

Bluemer, Julia
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany

Blankenfeldt, Wulf
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany

Goody, Roger S.
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany

Itzen, Aymelt
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44227 Dortmund, NRW, Germany
[35]
Modulation of Rab GTPase function by a protein phosphocholine transferase
[J].
Mukherjee, Shaeri
;
Liu, Xiaoyun
;
Arasaki, Kohei
;
McDonough, Justin
;
Galan, Jorge E.
;
Roy, Craig R.
.
NATURE,
2011, 477 (7362)
:103-U122

Mukherjee, Shaeri
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

Liu, Xiaoyun
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

Arasaki, Kohei
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

McDonough, Justin
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

Galan, Jorge E.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

Roy, Craig R.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA
[36]
Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis -: Critical role of the 16th leucine residue in EspF
[J].
Nagai, T
;
Abe, A
;
Sasakawa, C
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2005, 280 (04)
:2998-3011

Nagai, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Inst Med Sci, Dept Microbiol & Immun, Minato Ku, Tokyo 1088639, Japan

Abe, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Inst Med Sci, Dept Microbiol & Immun, Minato Ku, Tokyo 1088639, Japan

Sasakawa, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Inst Med Sci, Dept Microbiol & Immun, Minato Ku, Tokyo 1088639, Japan
[37]
De-AMPylation of the Small GTPase Rab1 by the Pathogen Legionella pneumophila
[J].
Neunuebel, M. Ramona
;
Chen, Yang
;
Gaspar, Andrew H.
;
Backlund, Peter S., Jr.
;
Yergey, Alfred
;
Machner, Matthias P.
.
SCIENCE,
2011, 333 (6041)
:453-456

Neunuebel, M. Ramona
论文数: 0 引用数: 0
h-index: 0
机构:
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA

Chen, Yang
论文数: 0 引用数: 0
h-index: 0
机构:
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA
Peking Univ, Ctr Hlth Sci, Beijing 100191, Peoples R China Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA

Gaspar, Andrew H.
论文数: 0 引用数: 0
h-index: 0
机构:
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA

Backlund, Peter S., Jr.
论文数: 0 引用数: 0
h-index: 0
机构:
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biomed Mass Spectrometry Facil, NIH, Bethesda, MD 20892 USA Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA

Yergey, Alfred
论文数: 0 引用数: 0
h-index: 0
机构:
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biomed Mass Spectrometry Facil, NIH, Bethesda, MD 20892 USA Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA

Machner, Matthias P.
论文数: 0 引用数: 0
h-index: 0
机构:
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA
[38]
Effector proteins translocated by Legionella pneumophila:: strength in numbers
[J].
Ninio, Shira
;
Roy, Craig R.
.
TRENDS IN MICROBIOLOGY,
2007, 15 (08)
:372-380

论文数: 引用数:
h-index:
机构:

Roy, Craig R.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Sect Microbial Pathogenesis, Boyer Ctr Mol Med, New Haven, CT 06536 USA Yale Univ, Sch Med, Sect Microbial Pathogenesis, Boyer Ctr Mol Med, New Haven, CT 06536 USA
[39]
Enteropathogenic Escherichia coli EspF is targeted to mitochondria and is required to initiate the mitochondrial death pathway
[J].
Nougayrède, JP
;
Donnenberg, MS
.
CELLULAR MICROBIOLOGY,
2004, 6 (11)
:1097-1111

Nougayrède, JP
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Baltimore Sch Med, Div Infect Dis, Baltimore, MD 21201 USA Univ Maryland, Baltimore Sch Med, Div Infect Dis, Baltimore, MD 21201 USA

Donnenberg, MS
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Baltimore Sch Med, Div Infect Dis, Baltimore, MD 21201 USA Univ Maryland, Baltimore Sch Med, Div Infect Dis, Baltimore, MD 21201 USA
[40]
Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation
[J].
Ohlson, Maikke B.
;
Huang, Zhiwei
;
Alto, Neal M.
;
Blanc, Marie-Pierre
;
Dixon, Jack E.
;
Chai, Jijie
;
Miller, Samuel I.
.
CELL HOST & MICROBE,
2008, 4 (05)
:434-446

Ohlson, Maikke B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USA Nat Inst Biol Sci, Beijing 102206, Peoples R China

Huang, Zhiwei
论文数: 0 引用数: 0
h-index: 0
机构:
Nat Inst Biol Sci, Beijing 102206, Peoples R China Nat Inst Biol Sci, Beijing 102206, Peoples R China

Alto, Neal M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA Nat Inst Biol Sci, Beijing 102206, Peoples R China

Blanc, Marie-Pierre
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USA Nat Inst Biol Sci, Beijing 102206, Peoples R China

Dixon, Jack E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA Nat Inst Biol Sci, Beijing 102206, Peoples R China

Chai, Jijie
论文数: 0 引用数: 0
h-index: 0
机构:
Nat Inst Biol Sci, Beijing 102206, Peoples R China Nat Inst Biol Sci, Beijing 102206, Peoples R China

Miller, Samuel I.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
Univ Washington, Dept Med, Seattle, WA 98195 USA
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA Nat Inst Biol Sci, Beijing 102206, Peoples R China