Huntingtin: a single bait hooks many species

被引：59

作者：

Gusella, JF ^{[1
]}

MacDonald, ME ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Mol Neurogenet Unit, Charlestown, MA 02129 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(98)80071-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cloning of the Huntington's disease gene uncovered huntingtin, which is remarkable for its lack of similarity with known proteins despite its large size, similar to 350 kDa. Subsequent experiments established that huntingtin has an as yet unknown function, crucial for embryonic development and neurogenesis. Recent protein trapping to identify huntingtin interactors now reveals that many different prey fall victim to huntingtin bait.

引用

页码：425 / 430

页数：6

共 56 条

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