Changes in conjugated linoleic acid composition within samples obtained from a single source

被引：11

作者：

Adlof, RO ^{[1
]}

Copes, LC ^{[1
]}

Walter, EL ^{[1
]}

机构：

[1] ARS, Natl Ctr Agr Utilizat Res, USDA, Peoria, IL 61604 USA

来源：

LIPIDS | 2001年 / 36卷 / 03期

关键词：

conjugated; linoleic; CLA; composition; isomers; HPLC; GC;

D O I：

10.1007/s11745-001-0723-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Conjugated linoleic acid (CLA; 9c,11t-18:2) and CLA isomers have been reported, in animals, to exhibit a variety of health-related benefits. Silver ion high-performance liquid chromatography (Ag-HPLC) was found to provide better resolution of the isomers than gas chromatography. Most commercially available samples of CLA, prepared by base-catalyzed isomerization of linoleic acid (9c,12c-18:2), are composed of mixtures of four major isomers. While these isomers have been characterized, we found significant changes in CLA isomer ratios within samples obtained from the same producer/commercial supplier over a period of 1.5 yr. In the first sample, the four cis/trans isomers (8t,10c-18:2, 9c,11t-18:2, 10t,12c-18:2 and 11c,13t-18:2) were present in a ratio of approximately 1:2:2:1, while in the second sample they were present in almost equal proportions. If indeed certain daily levels of CLA intake are required to produce suggested health benefits in humans, changes in concentrations of specific CLA isomers could significantly impact these effects. Care must be taken to analyze the CLA used in human and animal studies.

引用

页码：315 / 317

页数：3

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