Directed antibody-engineering techniques and their applications in food immunoassays

被引：12

作者：

Markus, Vehniainen ^{[1
]}

Janne, Leivo ^{[1
]}

Urpo, Lamminmaki ^{[1
]}

机构：

[1] Univ Turku, Dept Biochem & Food Chem, FIN-20540 Turku, Finland

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2011年 / 30卷 / 02期

关键词：

Antibody; Directed antibody engineering; Food immunoassay; Food quality; Food safety; Immunoanalysis; Immunodiagnostics; Recombinant antibody; SPECIFICITY HAPTEN RECOGNITION; VARIABLE FRAGMENT ANTIBODY; SITE-SPECIFIC MUTAGENESIS; SINGLE-DOMAIN ANTIBODIES; PHAGE DISPLAY LIBRARY; ESCHERICHIA-COLI; HETEROPHILIC ANTIBODIES; AFFINITY MATURATION; PROTEIN EVOLUTION; CROSS-REACTIVITY;

D O I：

10.1016/j.trac.2011.01.001

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of antibodies in immunodiagnostics has achieved new insights with recombinant technologies. This review summarizes the methods used to produce recombinant antibodies and those to tailor their properties. Finally, we address the advantages and the possibilities of recombinant antibodies in immunoanalytical applications through examples with the main focus on applications related to food quality and safety analysis. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：219 / 226

页数：8

共 69 条

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