Sitostanetriol is not formed in vivo from sitosterol in the rat

被引：13

作者：

Grandgirard, A ^{[1
]}

Martine, L ^{[1
]}

Juanéda, P ^{[1
]}

Cordelet, C ^{[1
]}

机构：

[1] INRA, Unite Nutr Lipid, F-21065 Dijon, France

来源：

REPRODUCTION NUTRITION DEVELOPMENT | 2004年 / 44卷 / 06期

关键词：

phytosterol; oxyphytosterol; sitostanetriol; plasma;

D O I：

10.1051/rnd:2004057

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In a recent study, we observed some oxyphytosterols in the plasma of healthy human subjects. This experiment was effected in order to determine if these compounds could be formed in vivo from phytosterols. Rats were fed with a high level of phytosterols (1% of the diet) and they were compared to rats deprived of phytosterols, using triglycerides purified from phytosterols. Their plasma were analysed for the main oxyphytosterols. The results show that sitostanetriol and campestanetriol were not formed in vivo from phytosterols. Their levels decreased during the experiment. The diet origin is highly probable for the compounds identified in human plasma. In particular, it seems that the sitostanetriol is eliminated very slowly from the organism.

引用

页码：609 / 616

页数：8

共 27 条

[1] USE OF AN O-18(2) INHALATION TECHNIQUE AND MASS ISOTOPOMER DISTRIBUTION ANALYSIS TO STUDY OXYGENATION OF CHOLESTEROL IN RAT - EVIDENCE FOR IN-VIVO FORMATION OF 7-OXOCHOLESTEROL, 7-BETA-HYDROXYCHOLESTEROL, 24-HYDROXYCHOLESTEROL, AND 24-HYDROXYCHOLESTEROL [J].