Screening of medicinal plants used in South African traditional medicine for genotoxic effects

被引：92

作者：

Elgorashi, EE

Taylor, JLS

Maes, A

van Staden, J

De Kimpe, N

Verschaeve, L

机构：

[1] Univ Ghent, Fac Agr & Appl Biol Sci, Dept Organ Chem, B-9000 Ghent, Belgium

[2] Vlaamse Instelling Technol Onderzoek, Flemish Inst Technol Res, Div Environm Toxicol, B-2400 Mol, Belgium

[3] Univ Natal Pietermaritzburg, Res Ctr Plant Growth & Dev, ZA-3209 Scottsville, South Africa

来源：

TOXICOLOGY LETTERS | 2003年 / 143卷 / 02期

关键词：

plant extracts; medicinal plants; genotoxicity; ames test; VITOTOX (R) test;

D O I：

10.1016/S0378-4274(03)00176-0

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Dichloromethane and 90% methanol extracts from 51 South African medicinal plants were evaluated for potential genotoxic effects using the bacterial Ames and VITOTOX(R) tests with and without metabolic activation. Dichloromethane extracts from bulbs of Crinum macowanii showed mutagenicity in strain TA98 with and without metabolic activation, whereas extracts from leaves of Chaetacme aristata and foliage of Plumbago auriculata showed mutagenicity and/or toxicity. Extracts from the leaves of Catharanthus roseus and twigs of Combretum mkhzense were mutagenic with metabolic activation only. The only 90% methanol extracts that were mutagenic in strain TA98 were from the leaves of C roseus and Ziziphus mucronata in the presence of metabolic activation. No genotoxic effects were found in strain TA100 or in the VITOTOX(R) test. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：195 / 207

页数：13