Towards the asymmetric synthesis of bryostatin 1

被引:17
作者
DeBrabander, J
Vandewalle, M
机构
[1] University of Gent, Department of Organic Chemistry, Laboratory for Organic Synthesis, B-9000 Gent, Krijgslaan
关键词
D O I
10.1351/pac199668030715
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The construction of the fragments C-1-C-9 3 and C-17-C-27 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described, The usefulness of the ''chiron'' approach is illustrated with the synthesis of these fragments from respectively D-pantolactone (6) and D-isobutyl lactate (14) as chiral templates.
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页码:715 / 718
页数:4
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