Tau suppression in a neurodegenerative mouse model improves memory function

被引：1530

作者：

SantaCruz, K

Lewis, J

Spires, T

Paulson, J

Kotilinek, L

Ingelsson, M

Guimaraes, A

DeTure, M

Ramsden, M

McGowan, E

Forster, C

Yue, M

Orne, J

Janus, C

Mariash, A

Kuskowski, M

Hyman, B

Hutton, M

Ashe, KH ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Neurol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Med, Dept Neurosci, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Sch Med, Grad Program Neurosci, Minneapolis, MN 55455 USA

[5] Mayo Clin Jacksonville, Dept Neurosci, Jacksonville, FL 32224 USA

[6] Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA

[7] Minneapolis VA Hosp, Ctr Geriatr Res Educ & Clin, Minneapolis, MN 55417 USA

来源：

SCIENCE | 2005年 / 309卷 / 5733期

关键词：

D O I：

10.1126/science.1113694

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating, neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.

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收藏

页码：476 / 481

页数：6

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