Mild Cognitive Impairment

被引:998
作者
Petersen, Ronald C. [1 ,2 ]
机构
[1] Mayo Clin, Dept Neurol, Coll Med, Rochester, MN 55905 USA
[2] Mayo Clin, Alzheimers Dis Res Ctr, Rochester, MN 55905 USA
关键词
ALZHEIMERS-DISEASE; CSF BIOMARKERS; CLINICAL CHARACTERIZATION; AMYLOID DEPOSITION; AMERICAN-ACADEMY; FOLLOW-UP; DEMENTIA; PREVALENCE; PROGRESSION; PREDICTION;
D O I
10.1056/NEJMcp0910237
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 70-year-old woman has been noticing increasing forgetfulness over the past 6 to 12 months. Although she has always had some difficulty recalling the names of acquaintances, she is now finding it difficult to keep track of appointments and recent telephone calls, but the process has been insidious. She lives independently in the community; she drives a car, pays her bills, and is normal in appearance. A mental status examination revealed slight difficulty on delayed recall of four words, but the results were otherwise normal. Does the patient have mild cognitive impairment? How should her case be managed?
引用
收藏
页码:2227 / 2234
页数:8
相关论文
共 52 条
[21]   Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease [J].
Jack, Clifford R., Jr. ;
Wiste, Heather J. ;
Vemuri, Prashanthi ;
Weigand, Stephen D. ;
Senjem, Matthew L. ;
Zeng, Guang ;
Bernstein, Matt A. ;
Gunter, Jeffrey L. ;
Pankratz, Vernon S. ;
Aisen, Paul S. ;
Weiner, Michael W. ;
Petersen, Ronald C. ;
Shaw, Leslie M. ;
Trojanowski, John Q. ;
Knopman, David S. .
BRAIN, 2010, 133 :3336-3348
[22]  
JACK CR, ALZHEIMERS IN PRESS
[23]   Relationships between biomarkers in aging and dementia [J].
Jagust, W. J. ;
Landau, S. M. ;
Shaw, L. M. ;
Trojanowski, J. Q. ;
Koeppe, R. A. ;
Reiman, E. M. ;
Foster, N. L. ;
Petersen, R. C. ;
Weiner, M. W. ;
Price, J. C. ;
Mathis, C. A. .
NEUROLOGY, 2009, 73 (15) :1193-1199
[24]   Cognitive Intervention Programs for Individuals With Mild Cognitive Impairment: Systematic Review of the Literature [J].
Jean, Leonie ;
Bergeron, Marie-Eve ;
Thivierge, Stephanie ;
Simard, Martine .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2010, 18 (04) :281-296
[25]   Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B [J].
Klunk, WE ;
Engler, H ;
Nordberg, A ;
Wang, YM ;
Blomqvist, G ;
Holt, DP ;
Bergström, M ;
Savitcheva, I ;
Huang, GF ;
Estrada, S ;
Ausén, B ;
Debnath, ML ;
Barletta, J ;
Price, JC ;
Sandell, J ;
Lopresti, BJ ;
Wall, A ;
Koivisto, P ;
Antoni, G ;
Mathis, CA ;
Långström, B .
ANNALS OF NEUROLOGY, 2004, 55 (03) :306-319
[26]   Neuropathology of cognitively normal elderly [J].
Knopman, DS ;
Parisi, JE ;
Salviati, A ;
Floriach-Robert, M ;
Boeve, BF ;
Ivnik, RJ ;
Smith, GE ;
Dickson, DW ;
Johnson, KA ;
Petersen, LE ;
McDonald, WC ;
Braak, H ;
Petersen, RC .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2003, 62 (11) :1087-1095
[27]   Comparing predictors of conversion and decline in mild cognitive impairment [J].
Landau, S. M. ;
Harvey, D. ;
Madison, C. M. ;
Reiman, E. M. ;
Foster, N. L. ;
Aisen, P. S. ;
Petersen, R. C. ;
Shaw, L. M. ;
Trojanowski, J. Q. ;
Jack, C. R., Jr. ;
Weiner, M. W. ;
Jagust, W. J. .
NEUROLOGY, 2010, 75 (03) :230-238
[28]  
Lautenschlager NT, 2009, JAMA-J AM MED ASSOC, V301, P276
[29]   Prevalence and classification of mild cognitive impairment in the cardiovascular health study cognition study part 1 [J].
Lopez, OL ;
Jagust, WJ ;
DeKosky, ST ;
Becker, JT ;
Fitzpatrick, A ;
Dulberg, C ;
Breitner, J ;
Lyketsos, C ;
Jones, B ;
Kawas, C ;
Carlson, M ;
Kuller, LH .
ARCHIVES OF NEUROLOGY, 2003, 60 (10) :1385-1389
[30]   Frequency and course of mild cognitive impairment in a multiethnic community [J].
Manly, Jennifer J. ;
Tang, Ming-X. ;
Schupf, Nicole ;
Stern, Yaakov ;
Vonsattel, Jean-Paul G. ;
Mayeux, Richard .
ANNALS OF NEUROLOGY, 2008, 63 (04) :494-506