共 10 条
Connecting mitochondria and innate immunity
被引:96
作者:

McWhirter, SM
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机构:
Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

tenOever, BR
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机构:
Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

Maniatis, T
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机构:
Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
机构:
[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
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D O I:
10.1016/j.cell.2005.08.026
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Viral infection results in the activation of multiple signaling pathways, but how these pathways are coordinated remains a mystery. Two studies, one published in this issue of Cell (Seth et al., 2005) and the other in Molecular Cell (Xu et al., 2005), identify a new intracellular signaling protein that is required for activating type I interferon expression in response to viral infection. In addition, Seth et al. (2005) show that the function of this protein, which they call MAVS, requires that it be localized to the mitochondria. This observation establishes an unexpected link between innate immunity and an organelle with evolutionary origins in aerobic bacteria.
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页码:645 / 647
页数:3
相关论文
共 10 条
[1]
Toll-like receptor signalling
[J].
Akira, S
;
Takeda, K
.
NATURE REVIEWS IMMUNOLOGY,
2004, 4 (07)
:499-511

Akira, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Osaka 5650871, Japan

论文数: 引用数:
h-index:
机构:
[2]
A FADD-dependent innate immune mechanism in mammalian cells
[J].
Balachandran, S
;
Thomas, E
;
Barber, GN
.
NATURE,
2004, 432 (7015)
:401-405

Balachandran, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

Thomas, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

Barber, GN
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA
[3]
Ubiquitin signalling in the NF-κB pathway
[J].
Chen, ZJJ
.
NATURE CELL BIOLOGY,
2005, 7 (08)
:758-U19

Chen, ZJJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
[4]
RIGging an antiviral defense -: it's in the CARDs
[J].
Levy, DE
;
Marié, IJ
.
NATURE IMMUNOLOGY,
2004, 5 (07)
:699-701

Levy, DE
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Pathol, New York, NY 10016 USA NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

Marié, IJ
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
[5]
Structure and function of the interferon-β enhanceosome
[J].
Maniatis, T
;
Falvo, JV
;
Kim, TH
;
Kim, TK
;
Lin, CH
;
Parekh, BS
;
Wathelet, MG
.
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY,
1998, 63
:609-620

Maniatis, T
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

Falvo, JV
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

Kim, TH
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

Kim, TK
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

Lin, CH
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

Parekh, BS
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

Wathelet, MG
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[6]
Large-scale identification and characterization of human genes that activate NF-κB and MAPK signaling pathways
[J].
Matsuda, A
;
Suzuki, Y
;
Honda, G
;
Muramatsu, S
;
Matsuzaki, O
;
Nagano, Y
;
Doi, T
;
Shimotohno, K
;
Harada, T
;
Nishida, E
;
Hayashi, H
;
Sugano, S
.
ONCOGENE,
2003, 22 (21)
:3307-3318

Matsuda, A
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Suzuki, Y
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Honda, G
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Muramatsu, S
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Matsuzaki, O
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Nagano, Y
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Doi, T
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Shimotohno, K
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Harada, T
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Nishida, E
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Hayashi, H
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan

Sugano, S
论文数: 0 引用数: 0
h-index: 0
机构: ASAHI KASEI Corp, Hlth Care Co, Life Sci Res Inst, Biol Lab, Fuji, Shizuoka 4168501, Japan
[7]
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3
[J].
Seth, RB
;
Sun, LJ
;
Ea, CK
;
Chen, ZJJ
.
CELL,
2005, 122 (05)
:669-682

Seth, RB
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Howard Hughes Med Inst, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Howard Hughes Med Inst, Dallas, TX 75390 USA

Sun, LJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Howard Hughes Med Inst, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Howard Hughes Med Inst, Dallas, TX 75390 USA

Ea, CK
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Howard Hughes Med Inst, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Howard Hughes Med Inst, Dallas, TX 75390 USA

Chen, ZJJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, Dept Mol Biol, Howard Hughes Med Inst, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Howard Hughes Med Inst, Dallas, TX 75390 USA
[8]
How cells respond to interferons
[J].
Stark, GR
;
Kerr, IM
;
Williams, BRG
;
Silverman, RH
;
Schreiber, RD
.
ANNUAL REVIEW OF BIOCHEMISTRY,
1998, 67
:227-264

Stark, GR
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Lerner Res Inst, Cleveland, OH 44195 USA

Kerr, IM
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Lerner Res Inst, Cleveland, OH 44195 USA

Williams, BRG
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Lerner Res Inst, Cleveland, OH 44195 USA

Silverman, RH
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Lerner Res Inst, Cleveland, OH 44195 USA

Schreiber, RD
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Lerner Res Inst, Cleveland, OH 44195 USA
[9]
VISA is an adapter protein required for virus-triggered IFN-β signaling
[J].
Xu, LG
;
Wang, YY
;
Han, KJ
;
Li, LY
;
Zhai, ZH
;
Shu, HB
.
MOLECULAR CELL,
2005, 19 (06)
:727-740

Xu, LG
论文数: 0 引用数: 0
h-index: 0
机构: Natl Jewish Med & Res Ctr, Dept Immunol, Denver, CO 80206 USA

Wang, YY
论文数: 0 引用数: 0
h-index: 0
机构: Natl Jewish Med & Res Ctr, Dept Immunol, Denver, CO 80206 USA

Han, KJ
论文数: 0 引用数: 0
h-index: 0
机构: Natl Jewish Med & Res Ctr, Dept Immunol, Denver, CO 80206 USA

Li, LY
论文数: 0 引用数: 0
h-index: 0
机构: Natl Jewish Med & Res Ctr, Dept Immunol, Denver, CO 80206 USA

Zhai, ZH
论文数: 0 引用数: 0
h-index: 0
机构: Natl Jewish Med & Res Ctr, Dept Immunol, Denver, CO 80206 USA

Shu, HB
论文数: 0 引用数: 0
h-index: 0
机构: Natl Jewish Med & Res Ctr, Dept Immunol, Denver, CO 80206 USA
[10]
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
[J].
Yoneyama, M
;
Kikuchi, M
;
Natsukawa, T
;
Shinobu, N
;
Imaizumi, T
;
Miyagishi, M
;
Taira, K
;
Akira, S
;
Fujita, T
.
NATURE IMMUNOLOGY,
2004, 5 (07)
:730-737

Yoneyama, M
论文数: 0 引用数: 0
h-index: 0
机构: Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Dept Tumor Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan

Kikuchi, M
论文数: 0 引用数: 0
h-index: 0
机构: Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Dept Tumor Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan

Natsukawa, T
论文数: 0 引用数: 0
h-index: 0
机构: Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Dept Tumor Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan

Shinobu, N
论文数: 0 引用数: 0
h-index: 0
机构: Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Dept Tumor Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan

Imaizumi, T
论文数: 0 引用数: 0
h-index: 0
机构: Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Dept Tumor Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan

Miyagishi, M
论文数: 0 引用数: 0
h-index: 0
机构: Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Dept Tumor Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan

Taira, K
论文数: 0 引用数: 0
h-index: 0
机构: Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Dept Tumor Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan

Akira, S
论文数: 0 引用数: 0
h-index: 0
机构: Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Dept Tumor Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan

Fujita, T
论文数: 0 引用数: 0
h-index: 0
机构: Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Dept Tumor Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan