poly(propylene fumarate);
in situ polymerization;
injectable biomaterials;
orthopaedic biomaterials;
bone tissue engineering;
D O I:
10.1163/156856299X00423
中图分类号:
R318 [生物医学工程];
学科分类号:
0831 ;
摘要:
To synthesize high molecular weight poly(propylene fumarate) (PPF), fumaryl chloride and propylene glycol were reacted in the presence of potassium carbonate, which serves as a proton scavenger. Transesterification of the resulting low molecular weight oligomer led to a polymer with greater molecular weight than those from previous reaction methods without requiring the use of a catalyst. According to two-dimensional NMR, the backbone structure of this polymer was as expected and contained no byproducts formed by acid catalyzed addition across the fumarate double bond. Kinetic studies of the transesterification showed that the molecular weight reached a final M-n of 4900 (+/-700) and M-w of 9100 (+/-1300) after 16 h, while the polydispersity index remained below 1.8 throughout the reaction. Thus the PPF synthesized by the new method is of higher molecular weight and greater purity than our previously prepared material.
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页码:363 / 373
页数:11
相关论文
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[11]
Yaszemski M J, 1995, Tissue Eng, V1, P41, DOI 10.1089/ten.1995.1.41