New cycloalkylpyrazoles as potential cyclooxygenase inhibitors

被引：18

作者：

Cardia, MC ^{[1
]}

Corda, L ^{[1
]}

Fadda, AM ^{[1
]}

Maccioni, AM ^{[1
]}

Maccioni, E ^{[1
]}

Plumitallo, A ^{[1
]}

机构：

[1] Dept Farmacochimicotecnol, I-09124 Cagliari, Italy

来源：

FARMACO | 1998年 / 53卷 / 10-11期

关键词：

cycloalkyl-3-(N-substituted carbamoyl)-1-phenylpyrazoles; analgesic and antipyretic activity;

D O I：

10.1016/S0014-827X(98)00090-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study some cycloalkyl-3-(N-substituted carbamoyl)-1-phenylpyrazoles have been synthesized in order to screen their capability to inhibit human cyclooxygenase. The synthetic pathway is based on the well known property of nitrilimines to undergo 1,3-dipolar cycloaddition reactions. The structures of all the synthesized compounds have been elucidated by means of both analytical and spectroscopic methods. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：698 / 708

页数：11

共 22 条

[11]

FUSCO R, 1956, GAZZ CHIM ITAL, V86, P491

[12] 1.3-DIPOLARE CYCLOADDITIONEN .26. INTRAMOLEKULARE STABILISIERUNG BEI EINEM N-TRINITROPHENYL-NITRILLIMIN [J].