Solid-phase synthesis of tetramic acids

被引：38

作者：

Kulkarni, BA ^{[1
]}

Ganesan, A ^{[1
]}

机构：

[1] Natl Univ Singapore, Inst Mol & Cell Biol, Singapore 117609, Singapore

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 24期

关键词：

combinatorial chemistry; solid-phase synthesis; pyrrolidinones; condensations;

D O I：

10.1016/S0040-4039(98)00703-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Upon treatment with base, N-acylated alpha-amino acids loaded on Wang resin undergo cyclative Claisen-type condensation to release the tetramic acid in high yield and purity. The use of tetrabutylammonium hydroxide as base simplifies product purification, as it can be scavenged by acidic Amberlyst A-15 ion exchange resin. The diversity of the tetramic acids can be further increased by reductive alkylation of the starting amino acid. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4369 / 4372

页数：4

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