Modulated expression of secreted Frizzled-related proteins in human retinal degeneration

被引:46
作者
Jones, SE [1 ]
Jomary, C [1 ]
Grist, J [1 ]
Stewart, HJ [1 ]
Neal, MJ [1 ]
机构
[1] St Thomas Hosp, GKT, Rayne Inst,Div Pharmacol & Therapeut, Retinitis Pigmentosa Res Unit, London SE1 7EH, England
关键词
D O I
10.1097/00001756-200012180-00012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Inherited retinal degenerations such as retinitis pigmentosa (RP) are characterized by progressive loss of photoreceptors, apparently by apoptosis, and our recent report of increased secreted Frizzed-related protein-2 (SFRP2) in RP retinas suggests altered Wnt signalling may be a component of the degenerative process. The present study shows that levels of SFRP1, SFRP3 and SFRP5 mRNAs are also abnormal in RP, giving rise to idiosyncratic expression patterns. In highly degenerative retinas, the SFRP proteins localize mainly to the inner limiting membrane, but in a well-preserved retina SFRP1 and SFRP5 are notably localized to the surviving photoreceptors. Together with increased c-jun mRNA expression in all cases examined, these results support the notion that disruptions of Wnt network signalling are involved in retinal neurodegeneration. NeuroReport 11:3963-3967 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码:3963 / 3967
页数:5
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