Miniaturization of the structure elucidation of novel natural products -: Two trace antibacterial acylated caprylic alcohol glycosides from Arctostaphylos pumila

被引：29

作者：

Hu, JF ^{[1
]}

Yoo, HD ^{[1
]}

Williams, CT ^{[1
]}

Garo, E ^{[1
]}

Cremin, PA ^{[1
]}

Zeng, L ^{[1
]}

Vervoort, HC ^{[1
]}

Lee, CM ^{[1
]}

Hart, SM ^{[1
]}

Goering, MG ^{[1
]}

O'Neil-Johnson, M ^{[1
]}

Eldridge, GR ^{[1
]}

机构：

[1] Sequoia Sci Inc, Lead Discovery & Rapid Struct Elucidat Grp, San Diego, CA 92121 USA

来源：

PLANTA MEDICA | 2005年 / 71卷 / 02期

关键词：

high-throughput natural products chemistry; CapNMR (TM) probe; Arctostaphylos pumila; Ericaceae; acylated caprylic alcohol glycosides; antibacterial;

D O I：

10.1055/s-2005-837787

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

High-throughput isolation, purification and analysis methods applied to natural products libraries from plants gave rise to the discovery of two novel acylated caprylic alcohol glycosides (1, 2) produced by Arctostaphylos pumila. The NMR spectra were acquired using the CapNMR (TM) probe and performed on mass-limited samples, which enabled us to elucidate the structures of 2,6-diacetyl-3,4-diisobutyl-1-O-octylglucopyranoside (1, 200 pg) and 2,6-diacetyl-3,4-dimethylbutyl-1-O-octylglucopyranosid (2, 70 pg). Compounds 1 and 2 exhibited antibacterial activity against Gram-positive methicillin-resistant Staphylococcus aureus with an MIC of 128 mu g/mL and 64 mu g/mL, respectively.

引用

页码：176 / 180

页数：5