Mechanisms of eosinophil cytokine release

被引:32
作者
Bandeira-Melo, C
Weller, PF
机构
[1] Harvard Univ, Charles A Dana Res Inst, Harvard Thorndike Labs, Dept Med,Sch Med, Boston, MA 02215 USA
[2] Fiocruz MS, Inst Oswaldo Cruz, Dept Fisiol & Farmacodinam, Lab Imunofarmacol, BR-21045900 Rio De Janeiro, Brazil
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2005年 / 100卷
关键词
eosinophils; cytokines; degranulation;
D O I
10.1590/S0074-02762005000900013
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist preformed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C-4 within eosinophils where it acts as an intracrine mediator IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity.
引用
收藏
页码:73 / 81
页数:9
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