Silk fibroin microfluidic devices

被引：151

作者：

Bettinger, Christopher J.

Cyr, Kathleen M.

Matsumoto, Akira

Langer, Robert

Borenstein, Jeffrey T.

Kaplan, David L.

机构：

[1] Biomed Engn Ctr, Charles Stark Draper Lab, Cambridge, MA 02139 USA

[2] Tufts Univ, Sci & Technol Ctr, Dept Biomed Engn, Medford, MA 02155 USA

[3] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 19期

关键词：

D O I：

10.1002/adma.200602487

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microfluidic devices were fabricated from silk ribroin using an aqueous molding process adapted from soft lithography. The process results in mechanically robust, patent devices with macroscopic fluidic connections. Hepatocytes were seeded in the device and perfused for up to five days during which they exhibited liver-specific functions equivalent to that observed for standard tissue culture substrates.

引用

页码：2847 / +

页数：5

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