Investigation into the enantioselective protonation of enolate Schiff bases with (R)-pantolactone

被引：6

作者：

Calmès, M

Glot, C

Martinez, J

机构：

[1] Univ Montpellier 1, CNRS, UMR 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier 5, France

[2] Univ Montpellier 2, CNRS, UMR 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier 5, France

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(00)00500-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The effect of several factors on the enantioselective protonation of the enolates of a-amino acid derivatives with (R)-pantolactone were studied. The highest stereoselectivity (74-76% e.e.) was generally observed by associating lithium chloride with LHMDS and by using the optimum temperature for the formation of the enolate. (C) 2001 Published by Elsevier Science Ltd. All rights reserved.

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页码：49 / 52

页数：4

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